Involvement of a polyethylene glycol (PEG)-oxidizing enzyme in the bacterial metabolism of PEG.
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منابع مشابه
Immunogenicity of Polyethylene Glycol (PEG)
Covalent attachment of polyethylene glycol (PEG) to active proteins (PEGylation technology) successfully generated several FDA-approved compounds, including four blockbusters, which are considered non immunogenic. However, PEG antibodies and intolerance to the infusion were reported in some patients with gout treated with pegloticase, a PEG-uricase recently approved by the FDA (Food and Drug Ad...
متن کاملThe application of polyethylene glycol (PEG) to electron microscopy
The cytoplasm of cells from a variety of tissues has been viewed in sections (0.25-1 micrometers) devoid of any embedding resin. Glutaraldehyde- and osmium tetroxide-fixed tissues were infiltrated and embedded in a water-miscible wax, polyethylene glycol (PEG), and subsequently sectioned on dry glass or diamond knives. The PEG matrix was removed and the sections were placed on Formvarcarbon-pol...
متن کاملLow Volume Polyethylene Glycol (PEG) Plus Ascorbic Acid, a Valid Alternative to Standard PEG
Adequate bowel preparation is essential to improve colonoscopy quality. Inadequate bowel preparation may result in lower colonoscopy completion rate, longer duration of colonoscopy, and lower diagnostic yield for polyps. Polyethylene glycol (PEG) has been shown to be safe and effective, and thus regarded as the gold standard for bowel preparation before colonoscopy. However, the standard PEG re...
متن کاملSafety Evaluation of Polyethylene Glycol (PEG) Compounds for Cosmetic Use
Polyethylene glycols (PEGs) are products of condensed ethylene oxide and water that can have various derivatives and functions. Since many PEG types are hydrophilic, they are favorably used as penetration enhancers, especially in topical dermatological preparations. PEGs, together with their typically nonionic derivatives, are broadly utilized in cosmetic products as surfactants, emulsifiers, c...
متن کاملSensitivity of PEGylated interferon detection by anti-polyethylene glycol (PEG) antibodies depends on PEG length.
Attachment of poly(ethylene glycol) to proteins can mask immune epitopes to increase serum half-life, reduce immunogenicity, and enhance in vivo biological efficacy. However, PEGylation mediated epitope-masking may also limit sensitivity and accuracy of traditional ELISA. We previously described an anti-PEG-based sandwich ELISA for universal assay of PEGylated molecules. Here, we compared the q...
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ژورنال
عنوان ژورنال: Agricultural and Biological Chemistry
سال: 1984
ISSN: 0002-1369,1881-1280
DOI: 10.1271/bbb1961.48.1349